The Murciélago is a two-door, two-seat coupé. To celebrate the company's 40 years in operation, 50 special edition Murciélagos were built during the autumn of 2003.

An open-top version called the Murciélago Roadster was introduced in 2004 for the 2005 model year. The roadster features similar performance to the coupé with a more aggressive rear flank, as well as a considerably higher price tag.